biotin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	373	58-85-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: biotin coenzyme R D-Biotin	A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. Molecular weight: 244.31 Formula: C10H16N2O3S CLOGP: -0.08 LIPINSKI: 0 HAC: 5 HDO: 3 TPSA: 78.43 ALOGS: -2.30 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

biotin
coenzyme R
D-Biotin

A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.

Molecular weight: 244.31
Formula: C10H16N2O3S
CLOGP: -0.08
LIPINSKI: 0
HAC: 5
HDO: 3
TPSA: 78.43
ALOGS: -2.30
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.22 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	43 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.01 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	99 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Feb. 20, 1953	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Fatigue	103.01	12.12	801	32282	887227	62568712
Toxicity to various agents	86.22	12.12	13	33070	247237	63208702
Synovitis	84.09	12.12	3	33080	186915	63269024
Pleural thickening	83.07	12.12	37	33046	2846	63453093
Blood magnesium increased	81.21	12.12	37	33046	3001	63452938
Presbyacusis	80.09	12.12	36	33047	2829	63453110
Product dose omission issue	77.39	12.12	283	32800	234030	63221909
Pleural fibrosis	76.50	12.12	37	33046	3435	63452504
Contraindicated product administered	72.41	12.12	13	33070	217635	63238304
COVID-19	71.35	12.12	172	32911	112931	63343008
Deafness neurosensory	70.23	12.12	39	33044	4816	63451123
Hand deformity	70.22	12.12	3	33080	159454	63296485
Maternal exposure during pregnancy	65.37	12.12	17	33066	220045	63235894
Glossodynia	63.28	12.12	9	33074	178867	63277072
Epigastric discomfort	60.62	12.12	40	33043	6740	63449199
Alopecia	59.73	12.12	339	32744	337197	63118742
Dry eye	58.40	12.12	88	32995	40673	63415266
General physical health deterioration	57.12	12.12	17	33066	201385	63254554
Systemic lupus erythematosus	56.82	12.12	19	33064	208899	63247040
Cyst	55.19	12.12	51	33032	14048	63441891
Completed suicide	49.98	12.12	8	33075	145665	63310274
Headache	48.89	12.12	524	32559	632717	62823222
White blood cell count decreased	45.84	12.12	168	32915	138936	63317003
Back pain	40.71	12.12	256	32827	263889	63192050
Osteopenia	39.28	12.12	50	33033	19735	63436204
Diarrhoea	37.97	12.12	552	32531	714814	62741125
Acute kidney injury	37.91	12.12	49	33034	263366	63192573
Onychoclasis	37.79	12.12	29	33054	6193	63449746
Muscle spasms	37.49	12.12	171	32912	155979	63299960
Drug interaction	36.86	12.12	39	33044	229092	63226847
Blood potassium increased	35.92	12.12	46	33037	18263	63437676
Feeling abnormal	33.05	12.12	159	32924	148233	63307706
Drug ineffective	31.59	12.12	371	32712	1044394	62411545
Sinusitis	31.45	12.12	214	32869	226439	63229500
Hepatic enzyme increased	30.82	12.12	36	33047	202292	63253647
Wound	30.76	12.12	24	33059	163239	63292700
C-reactive protein increased	30.74	12.12	6	33077	94701	63361238
Full blood count decreased	30.14	12.12	51	33032	25973	63429966
Bone cyst	29.61	12.12	17	33066	2237	63453702
Pre-existing condition improved	28.79	12.12	28	33055	8216	63447723
Multiple sclerosis relapse	28.71	12.12	72	33011	48406	63407533
Osteosclerosis	27.83	12.12	20	33063	3868	63452071
Drug abuse	27.21	12.12	3	33080	72515	63383424
Lower respiratory tract infection	26.81	12.12	18	33065	132289	63323650
Exposure during pregnancy	26.70	12.12	25	33058	155522	63300417
Flatulence	26.55	12.12	57	33026	34645	63421294
Folliculitis	26.15	12.12	3	33080	70314	63385625
Multiple sclerosis	25.92	12.12	46	33037	24326	63431613
Intentional overdose	25.59	12.12	4	33079	74148	63381791
Skin lesion	25.29	12.12	52	33031	30669	63425270
Weight decreased	25.06	12.12	237	32846	276561	63179378
Febrile neutropenia	24.15	12.12	16	33067	118433	63337506
Memory impairment	24.14	12.12	113	32970	104145	63351794
Gastrooesophageal reflux disease	23.88	12.12	106	32977	95533	63360406
Constipation	23.65	12.12	199	32884	224744	63231195
Hot flush	23.31	12.12	69	33014	51090	63404849
Dermatitis atopic	23.25	12.12	27	33056	9697	63446242
Drug intolerance	23.02	12.12	83	33000	308578	63147361
Hyponatraemia	22.97	12.12	15	33068	111885	63344054
Stress	22.85	12.12	82	33001	67085	63388854
Dizziness	22.80	12.12	332	32751	429593	63026346
Cardiac arrest	22.51	12.12	10	33073	92535	63363404
Illness	22.19	12.12	66	33017	48993	63406946
Injection site pain	21.98	12.12	129	32954	129671	63326268
Hypoaesthesia	21.58	12.12	156	32927	168237	63287702
Liver injury	21.49	12.12	3	33080	60517	63395422
Injection site erythema	21.38	12.12	93	32990	83081	63372858
Swelling	21.23	12.12	73	33010	275305	63180634
Urinary tract infection	21.22	12.12	221	32862	264463	63191476
Infusion site haemorrhage	21.08	12.12	19	33064	5067	63450872
Surgery	20.91	12.12	53	33030	35859	63420080
Dry skin	20.68	12.12	71	33012	56816	63399123
Psoriasis	20.68	12.12	95	32988	86862	63369077
Migraine	20.36	12.12	107	32976	103239	63352700
Product use issue	20.19	12.12	54	33029	220466	63235473
Nausea	19.96	12.12	584	32499	853887	62602052
Pruritus	19.90	12.12	281	32802	361172	63094767
Arthropathy	19.65	12.12	60	33023	234732	63221207
Confusional state	19.37	12.12	61	33022	236319	63219620
Infusion site erythema	19.32	12.12	27	33056	11652	63444287
Osteoarthritis	18.98	12.12	99	32984	95244	63360695
Fall	18.87	12.12	298	32785	392036	63063903
Burning sensation	18.14	12.12	66	33017	54341	63401598
Overdose	18.03	12.12	20	33063	115058	63340881
Depressed level of consciousness	18.02	12.12	5	33078	62073	63393866
Somnolence	17.68	12.12	156	32927	178529	63277410
Pain in extremity	17.16	12.12	255	32828	331231	63124708
Flushing	17.09	12.12	81	33002	75006	63380933
Infusion related reaction	17.01	12.12	68	33015	245453	63210486
Hypokalaemia	16.31	12.12	18	33065	103786	63352153
Sinus disorder	16.17	12.12	38	33045	24515	63431424
Eosinophilic pleural effusion	15.93	12.12	4	33079	49	63455890
Dysgeusia	15.86	12.12	57	33026	46653	63409286
Nail disorder	15.73	12.12	26	33057	12989	63442950
Balance disorder	15.67	12.12	86	32997	84336	63371603
Increased tendency to bruise	15.42	12.12	23	33060	10529	63445410
Type 2 diabetes mellitus	15.38	12.12	7	33076	63861	63392078
Pancytopenia	15.02	12.12	17	33066	96916	63359023
Spinal operation	15.01	12.12	20	33063	8251	63447688
Vision blurred	14.69	12.12	90	32993	91834	63364105
Injection site mass	14.68	12.12	31	33052	18625	63437314
Gastrointestinal candidiasis	14.61	12.12	5	33078	189	63455750
Paraesthesia	14.48	12.12	135	32948	156831	63299108
Limb discomfort	14.42	12.12	41	33042	29675	63426264
Infusion site pain	14.41	12.12	29	33054	16840	63439099
Upper respiratory tract infection	14.18	12.12	82	33001	81965	63373974
Injection site bruising	14.11	12.12	51	33032	41859	63414080
Bone hypertrophy	14.03	12.12	6	33077	418	63455521
Infusion site swelling	13.85	12.12	21	33062	9749	63446190
Injection site swelling	13.63	12.12	55	33028	47517	63408422
Milk allergy	13.63	12.12	5	33078	232	63455707
Electrocardiogram QT prolonged	13.61	12.12	7	33076	59523	63396416
Muscle strain	13.50	12.12	19	33064	8255	63447684
Therapeutic response unexpected	13.42	12.12	30	33053	18729	63437210
Seasonal allergy	13.34	12.12	32	33051	20918	63435021
Vitamin D deficiency	13.23	12.12	25	33058	13867	63442072
Blood cholesterol abnormal	13.13	12.12	11	33072	2660	63453279
Food interaction	12.86	12.12	7	33076	831	63455108
Retinal disorder	12.80	12.12	9	33074	1681	63454258
Death	12.79	12.12	129	32954	374252	63081687
Gastrointestinal bacterial infection	12.74	12.12	7	33076	847	63455092
Polyarteritis nodosa	12.63	12.12	5	33078	286	63455653
Bradycardia	12.29	12.12	12	33071	73215	63382724
Acne	12.15	12.12	33	33050	23260	63432679
Drug-induced liver injury	12.13	12.12	3	33080	40219	63415720

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Fractional exhaled nitric oxide increased	202.41	23.51	44	5253	1038	34950596
Plantar fasciitis	163.24	23.51	42	5255	2074	34949560
Sensation of foreign body	161.10	23.51	44	5253	2739	34948895
Myoglobin blood increased	157.49	23.51	44	5253	2979	34948655
Brain natriuretic peptide increased	130.30	23.51	44	5253	5615	34946019
Secretion discharge	124.58	23.51	43	5254	5862	34945772
Appendicolith	101.85	23.51	41	5256	8560	34943074
Obstructive airways disorder	93.39	23.51	46	5251	15448	34936186
Exostosis	90.42	23.51	32	5265	4691	34946943
Dysphonia	86.10	23.51	50	5247	23333	34928301
Appendicitis	80.51	23.51	41	5256	14766	34936868
Dyspnoea exertional	75.24	23.51	58	5239	43221	34908413
Blood phosphorus increased	75.14	23.51	32	5265	7689	34943945
Stress	69.36	23.51	48	5249	30299	34921335
Ventricular fibrillation	68.76	23.51	43	5254	22911	34928723
Eosinophilia	65.93	23.51	44	5253	26178	34925456
Abdominal distension	65.79	23.51	61	5236	58431	34893203
Cardiogenic shock	62.94	23.51	43	5254	26575	34925059
Cardiac disorder	60.51	23.51	51	5246	43075	34908559
Wheezing	58.17	23.51	49	5248	41353	34910281
Muscle spasms	53.10	23.51	61	5236	74940	34876694
Nasopharyngitis	49.68	23.51	57	5240	69911	34881723
Dry mouth	49.29	23.51	39	5258	30126	34921508
Chest discomfort	46.64	23.51	49	5248	54481	34897153
Coronary artery disease	46.01	23.51	46	5251	48259	34903375
Myasthenia gravis	45.99	23.51	22	5275	6918	34944716
Ascites	45.56	23.51	45	5252	46526	34905108
Blood uric acid increased	41.94	23.51	23	5274	9601	34942033
Pneumothorax	36.25	23.51	27	5270	19065	34932569
Iron deficiency	35.47	23.51	17	5280	5364	34946270
Hyperphosphataemia	35.41	23.51	16	5281	4421	34947213
Blood cholesterol increased	32.35	23.51	26	5271	20517	34931117
Drug therapy	30.76	23.51	10	5287	1131	34950503
Needle fatigue	29.04	23.51	9	5288	872	34950762
Cough	28.30	23.51	67	5230	150073	34801561
Analgesic therapy	27.93	23.51	9	5288	989	34950645
Relapsing-remitting multiple sclerosis	27.49	23.51	9	5288	1041	34950593
Gait spastic	27.11	23.51	9	5288	1087	34950547
Atrial fibrillation	26.83	23.51	58	5239	122335	34829299
Multiple organ dysfunction syndrome	26.35	23.51	44	5253	76522	34875112
Hypertonic bladder	25.96	23.51	10	5287	1854	34949780
Hyponatraemia	25.16	23.51	45	5252	82646	34868988
Constipation	24.59	23.51	60	5237	136922	34814712
General physical health deterioration	23.90	23.51	57	5240	128212	34823422
Memory impairment	23.75	23.51	31	5266	43287	34908347
Sleep disorder therapy	23.71	23.51	8	5289	1015	34950619

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Alopecia	127.80	13.07	267	28459	231088	79484574
Fatigue	121.76	13.07	656	28070	929071	78786591
Toxicity to various agents	107.23	13.07	13	28713	421527	79294135
Presbyacusis	81.25	13.07	32	28694	2628	79713034
Pleural thickening	77.70	13.07	32	28694	2950	79712712
Acute kidney injury	72.78	13.07	49	28677	519355	79196307
Blood magnesium increased	72.71	13.07	32	28694	3474	79712188
Appendicolith	68.24	13.07	41	28685	8510	79707152
Pleural fibrosis	67.42	13.07	32	28694	4135	79711527
Product dose omission issue	65.45	13.07	217	28509	247320	79468342
Stress	65.33	13.07	109	28617	79503	79636159
Completed suicide	61.41	13.07	8	28718	245759	79469903
Drug interaction	58.35	13.07	39	28687	415144	79300518
Headache	56.19	13.07	415	28311	653357	79062305
Deafness neurosensory	54.85	13.07	33	28693	6865	79708797
Cyst	54.66	13.07	43	28683	13797	79701865
Epigastric discomfort	53.22	13.07	34	28692	7862	79707800
COVID-19	50.68	13.07	148	28578	157526	79558136
Dry eye	48.32	13.07	63	28663	36868	79678794
Multiple sclerosis relapse	45.44	13.07	69	28657	46464	79669198
Osteopenia	42.27	13.07	42	28684	18322	79697340
Nausea	40.67	13.07	524	28202	956672	78758990
Blood phosphorus increased	40.54	13.07	32	28694	10315	79705347
Abdominal distension	40.07	13.07	114	28612	119536	79596126
Onychoclasis	40.05	13.07	25	28701	5553	79710109
Appendicitis	39.66	13.07	43	28683	20751	79694911
White blood cell count decreased	38.60	13.07	152	28574	188136	79527526
Dry mouth	37.77	13.07	92	28634	87927	79627735
Feeling abnormal	35.49	13.07	132	28594	159067	79556595
Memory impairment	34.10	13.07	103	28623	111631	79604031
C-reactive protein increased	32.70	13.07	4	28722	129023	79586639
Relapsing-remitting multiple sclerosis	31.94	13.07	14	28712	1505	79714157
Osteosclerosis	31.58	13.07	19	28707	3952	79711710
Blood uric acid increased	31.57	13.07	31	28695	13329	79702333
Injection site pain	30.92	13.07	110	28616	129728	79585934
Blood potassium increased	30.86	13.07	45	28681	29230	79686432
Sinusitis	30.24	13.07	145	28581	195356	79520306
Back pain	29.46	13.07	199	28527	303981	79411681
Burning sensation	29.22	13.07	65	28661	58567	79657095
Constipation	29.12	13.07	188	28538	282862	79432800
Bone cyst	28.80	13.07	17	28709	3416	79712246
Cardio-respiratory arrest	28.41	13.07	3	28723	108507	79607155
Urinary tract infection	28.03	13.07	182	28544	274330	79441332
Injection site erythema	27.64	13.07	76	28650	78121	79637541
Multiple sclerosis	27.58	13.07	37	28689	22245	79693417
Febrile neutropenia	27.02	13.07	26	28700	230973	79484689
Myasthenia gravis	26.21	13.07	25	28701	10374	79705288
Pancytopenia	25.44	13.07	14	28712	165731	79549931
Ventricular fibrillation	25.23	13.07	43	28683	31883	79683779
Dizziness	25.18	13.07	295	28431	526146	79189516
Intentional overdose	25.17	13.07	4	28722	105956	79609706
Somnolence	24.73	13.07	159	28567	238822	79476840
Muscle spasms	24.46	13.07	126	28600	174604	79541058
Overdose	23.63	13.07	19	28707	184187	79531475
Hyperphosphataemia	23.45	13.07	19	28707	6357	79709305
Osteoarthritis	22.54	13.07	76	28650	87233	79628429
Migraine	22.45	13.07	76	28650	87417	79628245
Confusional state	22.35	13.07	51	28675	317946	79397716
Depressed level of consciousness	22.18	13.07	4	28722	96648	79619014
Weight decreased	22.12	13.07	210	28516	354988	79360674
Iron deficiency	22.03	13.07	23	28703	10631	79705031
Drug therapy	21.84	13.07	10	28716	1191	79714471
Cardiac arrest	21.77	13.07	18	28708	172078	79543584
Illness	21.44	13.07	50	28676	46461	79669201
Dermatitis atopic	21.31	13.07	22	28704	10034	79705628
Needle fatigue	21.22	13.07	9	28717	893	79714769
Dry skin	21.04	13.07	63	28663	67932	79647730
Skin lesion	20.41	13.07	46	28680	41798	79673864
Balance disorder	20.40	13.07	80	28646	98777	79616885
Cardiogenic shock	20.36	13.07	46	28680	41868	79673794
Maternal exposure during pregnancy	20.28	13.07	12	28714	136526	79579136
Analgesic therapy	20.25	13.07	9	28717	1000	79714662
Pain in extremity	20.02	13.07	210	28516	364328	79351334
Gastrooesophageal reflux disease	19.63	13.07	82	28644	104164	79611498
Pruritus	19.22	13.07	222	28504	394426	79321236
Hypoaesthesia	18.96	13.07	120	28606	179232	79536430
Injection site swelling	18.88	13.07	48	28678	47084	79668578
Gait spastic	18.78	13.07	9	28717	1188	79714474
Neutropenia	18.75	13.07	48	28678	287662	79428000
Diarrhoea	18.57	13.07	431	28295	880058	78835604
Full blood count decreased	18.45	13.07	34	28692	26785	79688877
Hypokalaemia	18.30	13.07	15	28711	144025	79571637
Contraindicated product administered	18.11	13.07	18	28708	157520	79558142
Hot flush	18.08	13.07	52	28674	54825	79660837
Renal failure	17.83	13.07	28	28698	200940	79514722
Central nervous system lesion	17.79	13.07	23	28703	13345	79702317
Pyrexia	17.64	13.07	158	28568	678551	79037111
Thrombocytopenia	17.48	13.07	44	28682	265215	79450447
Vitamin B12 deficiency	17.48	13.07	17	28709	7224	79708438
Cardiac failure	17.45	13.07	18	28708	154824	79560838
Respiratory failure	17.22	13.07	24	28702	180887	79534775
Pain	17.21	13.07	352	28374	703450	79012212
Pre-existing condition improved	17.20	13.07	15	28711	5548	79710114
Sleep disorder therapy	16.98	13.07	8	28718	1016	79714646
Injection site pruritus	16.87	13.07	43	28683	42240	79673422
Sleep disorder	16.60	13.07	68	28658	85609	79630053
Interstitial lung disease	16.58	13.07	10	28716	112590	79603072
Neck pain	16.35	13.07	62	28664	75355	79640307
Spinal operation	16.20	13.07	17	28709	7900	79707762
Blood cholesterol increased	15.87	13.07	66	28660	83654	79632008
Injection site mass	15.70	13.07	27	28699	20157	79695505
Hyperkalaemia	15.70	13.07	11	28715	114387	79601275
Injection site bruising	15.64	13.07	41	28685	40961	79674701
Flatulence	15.57	13.07	42	28684	42682	79672980
Mucosal inflammation	15.56	13.07	4	28722	75576	79640086
Hypotension	15.51	13.07	94	28632	440223	79275439
Glossodynia	15.46	13.07	9	28717	103328	79612334
Rhabdomyolysis	15.41	13.07	9	28717	103122	79612540
Deformity	15.15	13.07	18	28708	9587	79706075
Anxiety	14.99	13.07	146	28580	248366	79467296
Arthralgia	14.97	13.07	289	28437	571514	79144148
Dysgeusia	14.96	13.07	50	28676	57127	79658535
Pollakiuria	14.94	13.07	38	28688	37279	79678383
Dyspepsia	14.94	13.07	78	28648	108609	79607053
Eructation	14.88	13.07	19	28707	10890	79704772
Delirium	14.74	13.07	6	28720	84621	79631041
Fall	14.71	13.07	252	28474	487377	79228285
Drug-induced liver injury	14.61	13.07	3	28723	66114	79649548
Lower respiratory tract infection	14.58	13.07	15	28711	129205	79586457
Bone hypertrophy	14.39	13.07	6	28720	571	79715091
Hypertonic bladder	14.36	13.07	12	28714	4189	79711473
Metabolic acidosis	14.14	13.07	6	28720	82523	79633139
Milk allergy	14.12	13.07	4	28722	117	79715545
Regurgitation	13.99	13.07	10	28716	2777	79712885
Angioedema	13.90	13.07	5	28721	76030	79639632
Surgery	13.78	13.07	34	28692	32732	79682930
Systemic lupus erythematosus	13.74	13.07	14	28712	121135	79594527
Limb discomfort	13.73	13.07	34	28692	32816	79682846
Electrocardiogram QT prolonged	13.34	13.07	8	28718	90378	79625284
Vision blurred	13.20	13.07	74	28652	105824	79609838

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11HA05	ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations
MeSH PA	D018977	Micronutrients
MeSH PA	D014803	Vitamin B Complex
MeSH PA	D014815	Vitamins
CHEBI has role	CHEBI:23354	coenzymes
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:26348	prosthetic groups
CHEBI has role	CHEBI:50733	Dietary Supplement
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:78675	fundamental metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Biotin deficiency disease	indication	49607006
Biotinidase deficiency	off-label use	8808004	DOID:856
Propionic acidemia	off-label use	69080001	DOID:14701
Holocarboxylase synthase deficiency	off-label use	360369003	DOID:859
Constipation	contraindication	14760008	DOID:2089
Sarcoidosis	contraindication	31541009	DOID:11335
Dehydration	contraindication	34095006
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007
Osteolysis	contraindication	203522001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.79	acidic
pKa2	13.37	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Insulin-degrading enzyme	Enzyme	P14735	IDE_HUMAN		EC50	5.60		CHEMBL

External reference:

ID	Source
4017638	VUID
N0000146018	NUI
D00029	KEGG_DRUG
1588	RXNORM
C0005575	UMLSCUI
CHEBI:57586	CHEBI
BTN	PDB_CHEM_ID
CHEMBL857	ChEMBL_ID
DB00121	DRUGBANK_ID
D001710	MESH_DESCRIPTOR_UI
171548	PUBCHEM_CID
4787	IUPHAR_LIGAND_ID
1203	INN_ID
6SO6U10H04	UNII
11819	MMSL
118935	MMSL
118941	MMSL
41034	MMSL
d06867	MMSL
13813003	SNOMEDCT_US
8919000	SNOMEDCT_US
4017638	VANDF
4020110	VANDF
001035	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Strovite Forte Caplet	HUMAN PRESCRIPTION DRUG LABEL	19	0642-0204	TABLET, COATED	0.15 mg	ORAL	UNAPPROVED DRUG OTHER	15 sections
Strovite One Caplets	HUMAN PRESCRIPTION DRUG LABEL	20	0642-0207	TABLET	100 ug	ORAL	UNAPPROVED DRUG OTHER	14 sections
Strovite One Caplets	HUMAN PRESCRIPTION DRUG LABEL	20	0642-0207	TABLET	100 ug	ORAL	UNAPPROVED DRUG OTHER	14 sections
BACMIN	HUMAN PRESCRIPTION DRUG LABEL	19	0682-3001	TABLET, COATED	150 ug	ORAL	UNAPPROVED DRUG OTHER	10 sections
Dialyvite Supreme D	HUMAN PRESCRIPTION DRUG LABEL	13	10542-009	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite Supreme D	HUMAN PRESCRIPTION DRUG LABEL	13	10542-009	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite	HUMAN PRESCRIPTION DRUG LABEL	9	10542-010	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite	HUMAN PRESCRIPTION DRUG LABEL	9	10542-010	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite 5000	HUMAN PRESCRIPTION DRUG LABEL	12	10542-011	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite 5000	HUMAN PRESCRIPTION DRUG LABEL	12	10542-011	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite with Zinc	HUMAN PRESCRIPTION DRUG LABEL	10	10542-012	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite with Zinc	HUMAN PRESCRIPTION DRUG LABEL	10	10542-012	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite 3000	HUMAN PRESCRIPTION DRUG LABEL	12	10542-014	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Dialyvite 3000	HUMAN PRESCRIPTION DRUG LABEL	12	10542-014	TABLET, COATED	300 ug	ORAL	Unapproved drug other	7 sections
Quflora FE Pediatric Drops	HUMAN PRESCRIPTION DRUG LABEL	14	15370-102	LIQUID	3 ug	ORAL	UNAPPROVED DRUG OTHER	11 sections
Dialyvite	HUMAN PRESCRIPTION DRUG LABEL	9	17856-0010	TABLET, COATED	300 ug	ORAL	Unapproved drug other	8 sections
PNV-Select	HUMAN PRESCRIPTION DRUG LABEL	18	42192-320	TABLET, FILM COATED	300 ug	ORAL	unapproved drug other	10 sections
PNV-Omega	HUMAN PRESCRIPTION DRUG LABEL	13	42192-332	CAPSULE, GELATIN COATED	250 ug	ORAL	unapproved drug other	12 sections
HairQ-Plus	HUMAN OTC DRUG LABEL	1	49658-2001	SHAMPOO	0.06 mL	TOPICAL	unapproved drug other	8 sections
HairQ-Plus	HUMAN OTC DRUG LABEL	1	49658-4001	SOLUTION	0.06 mL	TOPICAL	unapproved drug other	8 sections
Bonogenhair care shampoo	HUMAN OTC DRUG LABEL	4	50653-1001	SHAMPOO	0.06 g	TOPICAL	unapproved drug other	4 sections
Bonogen Plushair care shampoo	HUMAN OTC DRUG LABEL	4	50653-2001	SHAMPOO	0.06 g	TOPICAL	unapproved drug other	4 sections
Bonogen Activatorhair loss treatment	HUMAN OTC DRUG LABEL	1	50653-3001	LIQUID	0.00 mL	TOPICAL	unapproved drug other	6 sections
Born Hair	HUMAN OTC DRUG LABEL	4	50653-4001	SHAMPOO	0.06 g	TOPICAL	unapproved drug other	7 sections
Doll Lash	HUMAN OTC DRUG LABEL	4	51329-1001	LIQUID	0.06 mL	TOPICAL	unapproved drug other	8 sections
Concept OB	HUMAN PRESCRIPTION DRUG LABEL	15	52747-620	CAPSULE	300 ug	ORAL	unapproved drug other	13 sections
Concept OB	HUMAN PRESCRIPTION DRUG LABEL	15	52747-620	CAPSULE	300 ug	ORAL	unapproved drug other	13 sections
Concept DHA	HUMAN PRESCRIPTION DRUG LABEL	15	52747-621	CAPSULE, LIQUID FILLED	300 ug	ORAL	unapproved drug other	7 sections
Concept DHA	HUMAN PRESCRIPTION DRUG LABEL	15	52747-621	CAPSULE, LIQUID FILLED	300 ug	ORAL	unapproved drug other	7 sections
Integra Plus	HUMAN PRESCRIPTION DRUG LABEL	10	52747-712	CAPSULE	300 ug	ORAL	unapproved drug other	12 sections